Taswell2018SDAIR

Title

Safety of Disclosing Amyloid Imaging Results to MCI and AD Patients
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Authors

Carl Taswell, Cheryl Donohue, Maree Mastwyk, Andrea Louey, Jacqueline Giummarra, Joanne Robertson, David Darby, Colin Masters, and Christopher Rowe

Affiliations

Brain Health Alliance, Ladera Ranch, California; University of California San Diego, La Jolla, California; Florey Inst Neuroscience & Mental Health, University of Melbourne, Parkville, VIC, Australia; Austin Health Dept Molecular Imaging, Melbourne, VIC, Australia

Abstract

Objective: To assess the psychological impact of disclosing a positive or negative amyloid brain scan result to symptomatic individuals with mild cognitive impairment (MCI) or mild Alzheimer's disease (AD). Design: Prospective longitudinal cohort study. Setting: Florey Institute of Neuroscience & Mental Health, University of Melbourne, Australia. Participants: A total of 133 individuals aged 50-85 with MCI or mild AD enrolled in the study with data collected between October 2014 and June 2016. Interventions: Disclosure of amyloid imaging results to participants. Measurements: Positron emission tomography (PET) brain amyloid imaging with [18F]-NAV4694; psychometric scales including the Center for Epidemiologic Studies Depression (CES-D) scale, Geriatric Depression Scale (GDS), Hospital Anxiety and Depression Scales (HADS-A and HADS-D) and State-Trait Anxiety Inventory (STAI) performed before and after disclosure of amyloid imaging results. Results: We did not observe any worsening of psychological health with a panel of psychometric scales assessed on individuals to whom amyloid brain scan results were disclosed. Conclusions: We consider it safe, without apparent risk of harm to patients, to disclose amyloid imaging results to patients who have no prior history of neuropsychiatric illness.

KeyPhrases

Alzheimer's disease, dementia, mild cognitive impairment, PET scan, brain amyloid imaging, risk disclosure, results disclosure.

Dates

published 2018-09-03, reprinted 2023-06-25.

Citation

Brainiacs Journal 2023 Volume 4 Issue 1 Edoc
DOI: 10.48085/X661B91A3
PDP: Nexus/Brainiacs/Taswell2018SDAIR
URL: BrainiacsJournal.org/arc/pub/Taswell2018SDAIR