Safety of Disclosing Amyloid Imaging Results to MCI and AD Patients
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- Carl Taswell, Cheryl Donohue, Maree Mastwyk, Andrea Louey, Jacqueline Giummarra, Joanne Robertson, David Darby, Colin Masters, and Christopher Rowe
- Brain Health Alliance, Ladera Ranch, California; University of California San Diego, La Jolla, California; Florey Inst Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia; Austin Health Dept Molecular Imaging, Melbourne, VIC, Australia
Objective: To assess the psychological impact of disclosing a positive or negative amyloid brain scan result to symptomatic individuals with mild cognitive impairment (MCI) or mild Alzheimer's disease (AD).
Design: Prospective longitudinal cohort study.
Setting: Florey Institute of Neuroscience \& Mental Health, University of Melbourne, Australia.
Participants: A total of 133 individuals aged 50--85 with MCI or mild AD enrolled in the study with data collected between October 2014 and June 2016.
Interventions: Disclosure of amyloid imaging results to participants.
Measurements: Positron emission tomography (PET) brain amyloid imaging with [18F]-NAV4694; psychometric scales including the Center for Epidemiologic Studies Depression (CES-D) scale, Geriatric Depression Scale (GDS), Hospital Anxiety and Depression Scales (HADS-A and HADS-D) and State-Trait Anxiety Inventory (STAI) performed before and after disclosure of amyloid imaging results.
Results: We did not observe any worsening of psychological health with a panel of psychometric scales assessed on individuals to whom amyloid brain scan results were disclosed.
Conclusions: We consider it safe, without apparent risk of harm to patients, to disclose amyloid imaging results to patients who have no prior history of neuropsychiatric illness.
- Alzheimer's disease, dementia, mild cognitive impairment, PET scan, brain amyloid imaging, risk disclosure, results disclosure.
Brainiacs Journal 2023 Volume 4 Issue 1 Edoc X661B91A3
- published 2018-09-03, reprinted 2023-06-25
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